《英文msh詞典》Heterozygosity Loss
[入口詞] Heterozygosity Loss
[主題詞] Loss of Heterozygosity
[英文釋義] The loss of one allele at a specific locus,caused by a deletion mutation; or loss of a chromosome from a chromosome pair,resulting in abnormal hemizygosity. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted. When this occurs at a tumor suppressor gene locus where one of the alleles is already abnormal,it can result in neoplastic transformation (CELL TRANSFORMATION,NEOPLASTIC).